Nyakeya returns from a short injury layoff for the AFC Leopards match.
Kimanzi has now clinched the award three times.
The result leaves us second with 26 points, two behind leaders Bandari.
Upfront, John Mwangi and Daniel Mwaura will play either side of Ronald Reagan in a new look attack.
The loss leaves us joint top with Bandari on 25 points.
Ahmed Ahmad gets his first start of the season replacing injured Cliff Nyakeya.